Skip to Main content Skip to Navigation
Journal articles

Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System

Abstract : Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that couples epigenetic regulation to gene transcription during the development of various tissues. It is involved in a variety of physiological responses under healthy and pathological conditions. Its role and mechanisms of action are best characterized in the immune and nervous systems. Furthermore, its implication in the development and homeostasis of other various tissues has also been reported. In the present review, we describe its role in skin development, adipogenesis, tooth formation and cranial suture ossification. Experimental data from several studies demonstrate the involvement of Bcl11b in the control of the balance between cell proliferation and differentiation during organ formation and repair, and more specifically in the context of stem cell self-renewal and fate determination. The impact of mutations in the coding sequences of Bcl11b on the development of diseases such as craniosynostosis is also presented. Finally, we discuss genome-wide association studies that suggest a potential influence of single nucleotide polymorphisms found in the 3' regulatory region of Bcl11b on the homeostasis of the cardiovascular system.
Document type :
Journal articles
Complete list of metadatas

https://hal.sorbonne-universite.fr/hal-03104567
Contributor : Gestionnaire Hal-Su <>
Submitted on : Saturday, January 9, 2021 - 11:08:23 AM
Last modification on : Monday, January 11, 2021 - 2:50:28 PM

File

fcell-08-581674.pdf
Publication funded by an institution

Identifiers

Citation

Marie-Thérèse Daher, Pedro Bausero, Onnik Agbulut, Zhenlin Li, Ara Parlakian. Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System. Frontiers in Cell and Developmental Biology, Frontiers media, 2020, 8, pp.581674. ⟨10.3389/fcell.2020.581674⟩. ⟨hal-03104567⟩

Share

Metrics

Record views

102

Files downloads

26