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Anticancer drugs and cardiovascular-related hospitalization in metastatic colorectal cancer: Insights from the AVOCETTE population-based study

Abstract : We aimed to investigate the association between anticancer drugs and cardiovascular-related hospitalization (CVRH) in metastatic colorectal cancer (mCRC) patients. A cohort study was conducted using the French county Calvados registry of digestive tumors. Incident mCRC cases between 2008 and 2014 were included. The follow-up end date was December 2016. Data from the county hospital center pharmacy and medical information departments were matched with the registry data. A competing risk approach was used. Statistical tests were two-sided. A total of 1,116 mCRC patients were included; they were administered 12,374 rounds of treatment; fluorouracil, oxaliplatin, irinotecan and bevacizumab were most common. A total of 208 CVRH events occurred in 145 patients (13.0%). The International Cancer Survival Standards type 1 standardized incidence was 84.0 CVRH per 1,000 person-years (95% confidence interval: 72.6-95.5). Anticancer drugs were not associated with a higher incidence of CVRH. Men, elderly patients, patients with a prior history of CVRH and patients with a higher Charlson comorbidity index were associated with a higher incidence of CVRH. CVRH was significantly associated with a higher all-cause mortality (multivariable hazard ratio for death 1.58, 95%CI 1.28-1.95). Anticancer drugs were not associated with a higher incidence of CVRH in mCRC patients.
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https://hal.sorbonne-universite.fr/hal-03099607
Contributor : Gestionnaire Hal-Su <>
Submitted on : Wednesday, January 6, 2021 - 11:31:42 AM
Last modification on : Monday, January 11, 2021 - 12:21:20 PM

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Charles Dolladille, Guy Launoy, Véronique Bouvier, Joe-Elie Salem, Damien Legallois, et al.. Anticancer drugs and cardiovascular-related hospitalization in metastatic colorectal cancer: Insights from the AVOCETTE population-based study. American Journal of Epidemiology, Oxford University Press (OUP), inPress, ⟨10.1093/aje/kwaa203⟩. ⟨hal-03099607⟩

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