Co-infection of SARS-CoV-2 with other respiratory viruses and performance of lower respiratory tract samples for the diagnosis of COVID-19

Sonia Burrel; Pierre Hausfater; Martin Dres; Valérie Pourcher; Charles-Edouard Luyt; Elisa Teyssou; Cathia Soulié; Vincent Calvez; Anne-Geneviève Marcelin; David Boutolleau

doi:10.1016/j.ijid.2020.10.040

Journal articles

Co-infection of SARS-CoV-2 with other respiratory viruses and performance of lower respiratory tract samples for the diagnosis of COVID-19

Sonia Burrel ^{1, 2} Pierre Hausfater ^{3, 4} Martin Dres ^{5, 6} Valérie Pourcher ^{1, 7} Charles-Edouard Luyt ^{3, 8} Elisa Teyssou ^{1, 2} Cathia Soulié ^{1, 2} Vincent Calvez ^{1, 2} Anne-Geneviève Marcelin ^{1, 2} David Boutolleau ^{1, 2}

1 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique

2 Service de virologie [CHU Pitié-Salpêtrière]

3 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition

4 Service d'Accueil des Urgences [CHU Pitié-Salpêtrière]

5 Neurophysiologie Respiratoire Expérimentale et Clinique

6 Département " R3S " - Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière]

7 Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière]

8 Institut de cardiologie [CHU Pitié-Salpêtrière]

Abstract : Objectives: This study was performed during the early outbreak period of coronavirus disease 2019 (COVID-19) and the seasonal epidemics of other respiratory viral infections, in order to describe the extent of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with other respiratory viruses. It also compared the diagnostic performances of upper respiratory tract (URT) and lower respiratory tract (LRT) samples for SARS-CoV-2 infection. Methods: From 25 January to 29 March 2020, all URT and LRT samples collected from patients with suspected COVID-19 received in the virology laboratory of Pitié-Salpêtrière University Hospital (Paris, France) were simultaneously tested for SARS-CoV-2 and other respiratory viruses. Results: A total of 1423 consecutive patients were tested: 677 (47.6%) males, 746 (52.4%) females, median age 50 (range, 1-103) years. Twenty-one (1.5%) patients were positive for both SARS-CoV-2 and other respiratory viruses. The detection rate of SARS-CoV-2 was significantly higher in LRT than in URT (53.6% vs. 13.4%; p<0.0001). The analysis of paired samples from 117 (8.2%) patients showed that SARS-CoV-2 load was lower in URT than in LRT samples in 65% of cases. Conclusion: The detection of other respiratory viruses in patients during this epidemic period could not rule out SARS-CoV-2 co-infection. Furthermore, LRT samples increased the accuracy of diagnosis of COVID-19.

Keywords : Co-infection Lower respiratory tract Other respiratory viruses SARS-CoV-2

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

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https://hal.sorbonne-universite.fr/hal-03105993
Contributor : Gestionnaire Hal-Su <>
Submitted on : Monday, January 11, 2021 - 3:01:33 PM
Last modification on : Tuesday, January 12, 2021 - 10:36:38 AM

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Co-infection of SARS-CoV-2 with other respiratory viruses and performance of lower respiratory tract samples for the diagnosis of COVID-19

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Co-infection of SARS-CoV-2 with other respiratory viruses and performance of lower respiratory tract samples for the diagnosis of COVID-19

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