Ex-Vivo Pharmacological Defatting of the Liver: A Review - Institut de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Medicine Année : 2021

Ex-Vivo Pharmacological Defatting of the Liver: A Review

Résumé

The ongoing organ shortage has forced transplant teams to develop alternate sources of liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising tool to assess viability and improve the function of organs from extended criteria donors, including fatty liver grafts. In particular, normothermic machine perfusion represents a powerful tool to test a liver in full 37 °C metabolism and add pharmacological corrections whenever needed. In this context, many pharmacological agents and therapeutics have been tested to induce liver defatting on normothermic machine perfusion with promising results even on human organs. This systematic review makes a comprehensive synthesis on existing pharmacological therapies for liver defatting, with special focus on normothermic liver machine perfusion as an experimental ex-vivo translational model. View Full-Text
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Dates et versions

hal-03177239 , version 1 (23-03-2021)

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Claire Goumard, Célia Turco, Mehdi Sakka, Lynda Aoudjehane, Philippe Lesnik, et al.. Ex-Vivo Pharmacological Defatting of the Liver: A Review. Journal of Clinical Medicine, 2021, 10 (6), pp.1253. ⟨10.3390/jcm10061253⟩. ⟨hal-03177239⟩
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