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Journal articles
Transition-Metal-Free α-Vinylation of Enolizable Ketones with β-Bromostyrenes
Abstract : An α-vinylation of enolizable ketones has been developed by using β-bromostyrenes and a KOtBu/NMP system. β,γ-Unsaturated ketones of E configuration were obtained in excellent yield and selectivity. Further synthetic possibilities are highlighted by one-pot functionalization via trapping of intermediate dienolates with alkyl, allyl, benzyl, and propargyl halides to generate quaternary centers. The reported transformation is believed to involve phenylacetylene and propargylic alcohol derivatives.
https://hal.umontpellier.fr/hal-02098027
Contributor : Odile Hennaut <>
Submitted on : Thursday, January 7, 2021 - 11:25:38 AM
Last modification on : Tuesday, February 9, 2021 - 11:24:48 AM
Contributor : Odile Hennaut <>
Submitted on : Thursday, January 7, 2021 - 11:25:38 AM
Last modification on : Tuesday, February 9, 2021 - 11:24:48 AM
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03 - Organic Letters 2019.pdf
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