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Autofluorescence-Free In Vivo Imaging Using Polymer-Stabilized Nd 3+ -Doped YAG Nanocrystals

Abstract : Neodymium-doped yttrium aluminum garnet (YAG:Nd3+) has been widely developed during roughly the past 60 years and has been an outstanding fluorescent material. It has been considered as the gold standard among multipurpose solid-state lasers. Yet, the successful downsizing of this system into the nanoregimen has been elusive, so far. Indeed, the synthesis of a garnet structure at the nanoscale, with enough crystalline quality for optical applications, was found to be quite challenging. Here, we present an improved solvothermal synthesis method producing YAG:Nd3+ nanocrystals of remarkably good structural quality. Adequate surface functionalization using asymmetric double-hydrophilic block copolymers, constituted of a metal-binding block and a neutral water-soluble block, provides stabilized YAG:Nd3+ nanocrystals with long-term colloidal stability in aqueous suspensions. These newly stabilized nanoprobes offer spectroscopic quality (long lifetimes, narrow emission lines, and large Stokes shifts) close to that of bulk YAG:Nd3+. The narrow emission lines of YAG:Nd3+ nanocrystals are exploited by differential infrared fluorescence imaging, thus achieving an autofluorescence-free in vivo readout. In addition, nanothermometry measurements, based on the ratiometric fluorescence of the stabilized YAG:Nd3+ nanocrystals, are demonstrated. The progress here reported paves the way for the implementation of this new stabilized YAG:Nd3+ system in the preclinical arena.
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https://hal.archives-ouvertes.fr/hal-03099455
Contributor : Geraldine Dantelle <>
Submitted on : Wednesday, January 6, 2021 - 10:49:09 AM
Last modification on : Tuesday, February 9, 2021 - 11:24:47 AM

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Alexandra Cantarano, Jingke Yao, Marija Matulionyte, José Lifante, Antonio Benayas, et al.. Autofluorescence-Free In Vivo Imaging Using Polymer-Stabilized Nd 3+ -Doped YAG Nanocrystals. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2020, 12 (46), pp.51273-51284. ⟨10.1021/acsami.0c15514⟩. ⟨hal-03099455⟩

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