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Article Dans Une Revue Journal of Breath Research Année : 2023

Assessment of an e-nose performance for the detection of COVID-19 specific biomarkers

Résumé

Early, rapid and non-invasive diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is needed for the prevention and control of coronavirus disease 2019 (COVID-19). COVID-19 mainly affects the respiratory tract and lungs. Therefore, analysis of exhaled breath could be an alternative scalable method for reliable SARS-CoV-2 screening. In the current study, an experimental protocol using an electronic-nose (‘e-nose’) for attempting to identify a specific respiratory imprint in COVID-19 patients was optimized. Thus the analytical performances of the Cyranose ® , a commercial e-nose device, were characterized under various controlled conditions. In addition, the effect of various experimental conditions on its sensor array response was assessed, including relative humidity, sampling time and flow rate, aiming to select the optimal parameters. A statistical data analysis was applied to e-nose sensor response using common statistical analysis algorithms in an attempt to demonstrate the possibility to detect the presence of low concentrations of spiked acetone and nonanal in the breath samples of a healthy volunteer. Cyranose ® reveals a possible detection of low concentrations of these two compounds, in particular of 25 ppm nonanal, a possible marker of SARS-CoV-2 in the breath.
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Dates et versions

cea-04080762 , version 1 (27-04-2023)

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Christelle Ghazaly, Krystyna Biletska, Etienne Thevenot, Philippe Devillier, Emmanuel Naline, et al.. Assessment of an e-nose performance for the detection of COVID-19 specific biomarkers. Journal of Breath Research, 2023, 17 (2), pp.026006. ⟨10.1088/1752-7163/acb9b2⟩. ⟨cea-04080762⟩
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