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Impact of Gender on the Characteristics of Patients with Idiopathic Pulmonary Fibrosis Included in the RaDiCo-ILD Cohort

Vincent Cottin 1, 2, * Sonia Gueguen 3 Stéphane Jouneau 4, 5 Hilario Nunes 6 Bruno Crestani 7 Philippe Bonniaud 8 Lidwine Wemeau-Stervinou 9 Martine Reynaud-Gaubert 10, 11 Dominique Israel-Biet 12 Jacques Cadranel 13 Sylvain Marchand-Adam 14 Sebastien Quetant 15 Sandrine Hirschi 16 David Montani 17 Anne-Sophie Gamez 18 Marie Chevereau 3 Isabelle Dufaure-Gare 3 Serge Amselem 3 Annick Clement 19 
Abstract : Background: There is growing evidence of gender-specific phenotypic differences among patients with idiopathic pulmonary fibrosis (IPF), which may affect patient outcomes. Objectives: We present the characteristics of patients with IPF at inclusion in the French Rare Disease Cohort - Interstitial Lung Disease (RaDiCo-ILD) with the aim of characterizing gender-specific phenotypic differences. Methods: Patients with IPF who were enrolled in the national, multicentre RaDiCo-ILD cohort were included. Demographic characteristics, comorbidities, health-related quality of life (HRQoL) scores, pulmonary function, chest imaging, and IPF treatment were collected at inclusion and described by gender. Results: The cohort included 724 patients with IPF (54% of RaDiCo-ILD cohort), of whom 82.9% were male. The proportion of male and female patients with a prior history of smoking was 75.0% and 26.8%, respectively. Emphysema was present in 17.0% (95% confidence interval [CI]: 10.0, 24.0) of men and 5.4% (95% CI: 1.2, 9.6) of women. At inclusion, females had poorer HRQoL than males based on St. George's Respiratory Questionnaire scores (48.5 [95% CI: 43.9, 53.0] and 41.5 [39.4, 43.6], respectively). The mean forced vital capacity per cent predicted was 77.7% (95% CI: 76.2, 79.3) and 87.4% (83.4, 91.4) for males and females, respectively. Honeycombing on high-resolution computed tomography (HRCT) was present in 70.8% (95% CI: 61.0, 80.6) of males and 45.8% (95% CI: 35.1, 56.5) of females. Conclusions: This analysis of patients with IPF at inclusion in the RaDiCo-ILD cohort provides evidence that comorbid emphysema, lung volume reduction, and honeycombing on HRCT are more common characteristics of males than females.
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Submitted on : Tuesday, October 26, 2021 - 4:49:08 PM
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Cottin et al - 2021 - Impact o...
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Vincent Cottin, Sonia Gueguen, Stéphane Jouneau, Hilario Nunes, Bruno Crestani, et al.. Impact of Gender on the Characteristics of Patients with Idiopathic Pulmonary Fibrosis Included in the RaDiCo-ILD Cohort. Respiration, Karger, 2022, 101 (1), pp.34-45. ⟨10.1159/000518008⟩. ⟨hal-03361027⟩