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LACK-Specific CD4 + T Cells That Induce Gamma Interferon Production in Patients with Localized Cutaneous Leishmaniasis during an Early Stage of Infection

Abstract : ABSTRACT The profile of cytokines induced by soluble leishmania antigen (SLA) and the Leishmania homologue of the mammalian receptor for activated C kinase (LACK), a candidate vaccine against leishmaniasis, and the cellular source of the cytokines produced in response to these antigens were analyzed in patients infected with Leishmania guyanensis . Gamma interferon (IFN-γ) and interleukin-10 (IL-10) were produced in response to LACK. Although LACK-specific CD4 + cells producing IFN-γ were isolated only during the early phase of infection (less than 30 days following the onset of infection), cells producing IL-10 in response to LACK were detected in all patients. CD4 + T cells producing IFN-γ and IL-13 were produced in response to SLA in all patients. SLA- and LACK-specific T cells are effector memory cells, as they are CD45RA − CCR7 − CD4 + T cells. CD4 + T cells producing IFN-γ are CD62L − , and CD4 + T cells producing IL-10 are CD62L + , indicating that these cells have different tissue-homing capacities. These findings show that SLA and LACK induce both type 1 (IFN-γ) and type 2 (IL-10 or IL-13) cell responses.
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https://hal.univ-guyane.fr/hal-03284783
Contributor : Mirlène Matillon <>
Submitted on : Monday, July 12, 2021 - 7:04:51 PM
Last modification on : Tuesday, July 13, 2021 - 3:36:58 AM

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Eliane Bourreau, Ghislaine Prévot, Jacques Gardon, Roger Pradinaud, Hitoshi Hasagewa, et al.. LACK-Specific CD4 + T Cells That Induce Gamma Interferon Production in Patients with Localized Cutaneous Leishmaniasis during an Early Stage of Infection. Infection and Immunity, American Society for Microbiology, 2002, 70 (6), pp.3122-3129. ⟨10.1128/iai.70.6.3122-3129.2002⟩. ⟨hal-03284783⟩

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