High Intralesional Interleukin‐10 Messenger RNA Expression in Localized Cutaneous Leishmaniasis Is Associated with Unresponsiveness to Treatment - Archive ouverte HAL Access content directly
Journal Articles Journal of Infectious Diseases Year : 2001

High Intralesional Interleukin‐10 Messenger RNA Expression in Localized Cutaneous Leishmaniasis Is Associated with Unresponsiveness to Treatment

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Eliane Bourreau
  • Function : Author
Jacques Gardon
  • Function : Author
Roger Pradinaud
  • Function : Author
Pascal Launois
  • Function : Author

Abstract

The intralesional expression of cytokines (interleukin [IL]-4, IL-13, IL-10, and interferon-gamma) was analyzed in 65 patients with localized cutaneous leishmaniasis due to Leishmania guyanensis before specific treatment with pentamidine isethionate. The local expression of IL-10 was significantly higher in patients who responded poorly to treatment than in patients whose lesions were regressing. When an IL-10 level >10 (ratio of the concentration of IL-10 [pg/microL] to that of beta-actin [pg/microL]) was used as an indicator of treatment failure, the sensitivity of this test was 78.6, and the specificity was 72.5. Thus, high intralesional expression of IL-10 might predict a poor response to conventional treatment.

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hal-03284786 , version 1 (12-07-2021)

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Eliane Bourreau, Ghislaine Prévot, Jacques Gardon, Roger Pradinaud, Pascal Launois. High Intralesional Interleukin‐10 Messenger RNA Expression in Localized Cutaneous Leishmaniasis Is Associated with Unresponsiveness to Treatment. Journal of Infectious Diseases, 2001, 184 (12), pp.1628-1630. ⟨10.1086/324665⟩. ⟨hal-03284786⟩

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