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High Intralesional Interleukin‐10 Messenger RNA Expression in Localized Cutaneous Leishmaniasis Is Associated with Unresponsiveness to Treatment

Abstract : The intralesional expression of cytokines (interleukin [IL]-4, IL-13, IL-10, and interferon-gamma) was analyzed in 65 patients with localized cutaneous leishmaniasis due to Leishmania guyanensis before specific treatment with pentamidine isethionate. The local expression of IL-10 was significantly higher in patients who responded poorly to treatment than in patients whose lesions were regressing. When an IL-10 level >10 (ratio of the concentration of IL-10 [pg/microL] to that of beta-actin [pg/microL]) was used as an indicator of treatment failure, the sensitivity of this test was 78.6, and the specificity was 72.5. Thus, high intralesional expression of IL-10 might predict a poor response to conventional treatment.
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https://hal.univ-guyane.fr/hal-03284786
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Submitted on : Monday, July 12, 2021 - 7:11:50 PM
Last modification on : Monday, September 20, 2021 - 5:15:21 PM

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Eliane Bourreau, Ghislaine Prévot, Jacques Gardon, Roger Pradinaud, Pascal Launois. High Intralesional Interleukin‐10 Messenger RNA Expression in Localized Cutaneous Leishmaniasis Is Associated with Unresponsiveness to Treatment. Journal of Infectious Diseases, Oxford University Press (OUP), 2001, 184 (12), pp.1628-1630. ⟨10.1086/324665⟩. ⟨hal-03284786⟩

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