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Unresponsiveness of Specific T Cells to IL-12 is Associated with Active Cutaneous Leishmaniasis Owing to Leishmania guyanensis

Abstract : The production of interleukin (IL)-13 and unresponsiveness to IL-12 in T cells were analyzed in patients with active localized cutaneous leishmaniasis (untreated or not responsive to treatment) and in patients who had been treated successfully for the disease. More IL-13 was produced by specific T cells in response to Leishmania guyanensis (L. guyanensis) antigens in active compared to in inactive leishmaniasis. Furthermore, unresponsiveness of specific T cells to IL-12 was detected only in patients with active leishmaniasis, i.e. in patients with detectable parasites such as untreated patients and patients unresponsive to treatment. These results support that IL-12 unresponsiveness of Leishmania-specific T cells is responsible for the persistence of infection.
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https://hal.univ-guyane.fr/hal-03284788
Contributor : Mirlène Matillon Connect in order to contact the contributor
Submitted on : Monday, July 12, 2021 - 7:15:03 PM
Last modification on : Tuesday, November 23, 2021 - 9:58:03 AM

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E. Bourreau, Ghislaine Prevot, R. Pradinaud, P. Launois. Unresponsiveness of Specific T Cells to IL-12 is Associated with Active Cutaneous Leishmaniasis Owing to Leishmania guyanensis. Scandinavian Journal of Immunology, Wiley, 2001, 54 (3), pp.335-339. ⟨10.1046/j.1365-3083.2001.00981.x⟩. ⟨hal-03284788⟩

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