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Interleukin (IL)–13 Is the Predominant Th2 Cytokine in Localized Cutaneous Leishmaniasis Lesions and Renders Specific CD4 + T Cells Unresponsive to IL‐12

Abstract : Semiquantitative reverse transcription-polymerase chain reaction analysis of leishmania lesion cytokine profile showed a Th2 cytokine expression pattern, as reflected by interleukin (IL)-4 and IL-13 mRNA expression. There was a predominance of IL-13 in most lesions from patients with American localized cutaneous leishmaniasis caused by Leishmania guyanensis. IL-13 production by peripheral blood mononuclear cells in response to specific leishmania antigens was confirmed in these patients. The absence of the second chain of the IL-12 receptor (IL-12Rbeta2) mRNA expression in lesions and the presence of specific IgE and IgG4 in some serum samples demonstrated the functional role of these Th2 cytokines. IL-13, unlike IL-4, rendered specific T cells unresponsive to IL-12 by inhibiting the expression of the IL-12Rbeta2 chain. These data establish the crucial role of IL-13 in human cutaneous leishmaniasis.
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https://hal.univ-guyane.fr/hal-03289289
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Submitted on : Friday, July 16, 2021 - 5:51:52 PM
Last modification on : Monday, September 20, 2021 - 5:07:57 PM

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Eliane Bourreau, Ghislaine Prévot, Roger Pradinaud, Pascal Launois. Interleukin (IL)–13 Is the Predominant Th2 Cytokine in Localized Cutaneous Leishmaniasis Lesions and Renders Specific CD4 + T Cells Unresponsive to IL‐12. Journal of Infectious Diseases, Oxford University Press (OUP), 2001, 183 (6), pp.953-959. ⟨10.1086/319249⟩. ⟨hal-03289289⟩

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